日本WT1腫瘤疫苗

KOKOWA?WT1腫瘤疫苗是獲得日本厚生省核準，由日本腫瘤醫學研究所股份有限公司（The Institution of Medical Oncology）出產的預防性廣譜腫瘤疫苗（Borad-spectrum tumor vaccine），可有用預防20余種癌癥。

WT1基因（Wilm tumor gene1）是從Wilms瘤(Wilms tumor)細胞平分離出來的一種含鋅指狀多肽的抑癌基因，2001年日本科學家Haruo Sugiyama啟動了針對WT1卵白的癌癥免疫治療的臨床研究，接下來全球掀起WT1的研究高潮，2009年美國國度癌癥研究所(National Cancer Institute,NCI)闡發對比了75個惡性腫瘤抗原，最終發現WT1是最佳的腫瘤抗原。

東西/原料

小我護照
赴日簽證
體檢單/日本病院預約單

方式/步調

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起首籌辦供給近3個月的體檢陳述與日本病院進行預約，大夫按照陳述判定是否高危人群，是否有需要打針WT1腫瘤疫苗。（腫瘤標記物、CT 、腫瘤基因篩查、免疫疫苗篩查）
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預約打針時候，繳納打針費用，擬定形當作打算單
3
打點赴日簽證：籌辦護照、照片2張（3.4*4.5厘米）、保單、3個月的銀行對帳單、收入證實、身份證復印件
4
抵達日本病院，進行KOKOWA?WT1腫瘤疫苗的打針
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3個月后復檢，腫瘤防復發患者腫瘤標記物削減；腫瘤預防客人CD3、CD4、CD8發生轉變、腫塊（若是有）變小，腫瘤標記物（若是有）削減。
CD3 是當作熟T 淋巴細胞概況標記；CD4T 細胞是輔助性T淋巴細胞，其本家兒要功能是加強吞噬細胞介導的抗傳染感化和加強B細胞介導的體液免疫應答；CD8T細胞是按捺/殺傷性T淋巴細胞，本家兒要功能是特異性直接殺傷靶細胞。
6
參考文獻
1、H. Sugiyama, WT1 (Wilms' Tumor Gene 1): Biology and Cancer Immunotherapy, Japanese Journal of Clinical Oncology, 10.1093/jjco/hyp194

2、Miwa H, Beran M, Saunders GF, et al. Expression of the Wilms tumor gene (WT1) in human leukemias. Leukemia, 1992, (6):405- 409.

3、OkaY, TsuboiA, OjiY. WT1 peptide vaccine for the treatment of cancer [J] .Curr Opin Immunol, 2008,20(2):211-220.

4、Menssen, H., Bertelmann, E., Bartelt, S. et al. J Wilms’ tumor gene (WT1) expression in lung canner, colon cancer and glioblastoma cell lines compared to freshly isolated tumor specimens (J). J Cancer Res Clin Oncol,2000.126(4) 226-232

5、LOEB DM,EVRON E, PATEL C B, et al. Wilms’ tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor specific promoter methylation [J] Cancer Res, 2001.61(3),921-925

6、MIYOSHI Y. ANDO A. EGAWA C. et al. High expression of Wilms’ tumor suppressor gene predicts poor prognosis in breast cancer patients [J] Clin Cancer Res, 2002.8(5):1167-1171

7、ZAPATA-BENAVIDES P, TUNA M, LOPEA-BERSTEIN G. et al. Downregulation of Wilms tumor 1 protein inhibits breast cancer proliferation [J] Biochem Biophys Res Common, 2002,295(4),784-790

8、Oka Y, Tsuboi A, Taguchi T, Osaki T, Kyo T, Nakajima H, et al. Induction of WT1 (Wilms’ tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression. Proc Natl Acad Sci USA 2004;101:13885– 90.

9、Ohminami H, Yasukawa M, Fujita S. HLA class I-restricted lysis of leukemia cells by a CD8t cytotoxic T-lymphocyte clone specific for WT1 peptide. Blood 2000;95:286–93.

10、H. Sugiyama, WT1 (Wilms' Tumor Gene 1): Biology and Cancer Immunotherapy, Japanese Journal of Clinical Oncology, 10.1093/jjco/hyp194, 40